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Träfflista för sökning "L773:1945 7197 OR L773:0021 972X ;pers:(Husebye Eystein S.);pers:(Grimelius Lars)"

Search: L773:1945 7197 OR L773:0021 972X > Husebye Eystein S. > Grimelius Lars

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  • Sköldberg, Filip, et al. (author)
  • Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells
  • 2003
  • In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 88:4, s. 1445-1452
  • Journal article (peer-reviewed)abstract
    • Patients with autoimmune polyendocrine syndrome type 1 often have autoantibodies against neurotransmitter synthesizing enzymes, including the pyridoxal phosphate-dependent enzymes glutamic acid decarboxylase and aromatic L-amino acid decarboxylase. Using a candidate approach, we have identified the histamine-synthesizing enzyme histidine decarboxylase, also pyridoxal phosphate dependent, as an autoantigen in this disorder. Anti-histidine decarboxylase antibodies reacting with in vitro translated antigen were found in 36/97 (37%) of autoimmune polyendocrine syndrome type 1 patients studied. The antibodies also reacted with the native enzyme in HMC-1 cell lysates and did not cross-react with the highly homologous aromatic L-amino acid decarboxylase. Anti-histidine decarboxylase antibodies were associated with a history of intestinal dysfunction (P = 0.017). Gastric and duodenal biopsies from a patient with anti-histidine decarboxylase antibodies were studied by immunohistochemistry. The oxyntic mucosa was found to lack the histamine producing enterochromaffin-like cells, suggestive of an autoimmune destruction. To our knowledge, this is the first report of autoantibodies against histidine decarboxylase and absence of gastric enterochromaffin-like cells.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Rönnblom, Anders (2)
Gustafsson, Jan (2)
Perheentupa, Jaakko (2)
Rorsman, Fredrik (2)
Grimelius, Lars (2)Undo refine
Portela-Gomes, Guida ... (2)
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Nilsson, Gunnar (2)
Betterle, Corrado (2)
Sköldberg, Filip (2)
Kämpe, Olle (1)
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University
Uppsala University (2)
Language
English (1)
Undefined language (1)
Year
2003 (2)

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